RANBP10 (RAN binding protein 10) is a protein-coding gene. Diseases associated with RANBP10 include lissencephaly, and among its related super-pathways are Development HGF signaling pathway. GO annotations related to this gene include Ran guanyl-nucleotide exchange factor activity and beta-tubulin binding. An important paralog of this gene is SPRYD3. Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.
Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met).
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