Anti-RAMP2 (aa 45-144) polyclonal antibody

Species Reactivity

Human

Immunogen

RAMP2 (NP_005845, 45 a.a. ~ 144 a.a) partial recombinant protein with GST tag. The sequence is LPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFA ELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSDPPED

Conjugate

Alternative Names

RAMP2; receptor (G protein-coupled) activity modifying protein 2; receptor activity-modifying protein 2; CRLR activity-modifying protein 2; receptor activity modifying protein 2; receptor-activity-modifying protein 2; receptor (calcitonin) activity modify

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

Pathway

Calcitonin-like ligand receptors; G alpha (s) signalling events; GPCR ligand binding; Signal Transduction