Anti-RALA monoclonal antibody, clone BU52E6

Antibody Isotype

IgG2b

Clone

BU52E6

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to Human RALA aa 1-203. (NP_005393)Sequence: MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADS YRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMES FAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRAEQWN VNYVETSAKTR

Conjugate

Application Notes

WB: 1/500 - 1/2000;

Alternative Names

RALA; v-ral simian leukemia viral oncogene homolog A (ras related); RAL; ras-related protein Ral-A; Ras family small GTP binding protein RALA; RAS like protein A; Ras related protein Ral A; RAS-like protein A; MGC48949;

Entrez Gene ID

UniProt ID

Antigen Description

Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

Pathway

Arf6 trafficking events, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; NGF signalling via TRKA from the plasma membrane, organism-specific biosystem; Pancreatic cancer, organism-specific biosystem; Pancreatic cancer, conserved biosystem; Pathways in cancer, organism-specific biosystem; Signal Transduction, organism-specific biosystem;