RAD18 (NP_064550, 332 a.a. ~ 430 a.a) partial recombinant protein with GST tag. The sequence is EKEIDEIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEKLSSVCMGQ EDNMTSVTNHFSQSKLDSPEELEPDREEDSSSCIDIQEV
Conjugate
Unconjugated
Target
Alternative Names
RAD18; RAD18 homolog (S. cerevisiae); RNF73; E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; RING finger protein 73; RAD18, S. cerevisiae, homolog; postreplication repair protein RAD18; postreplication repair protein hRAD18p;
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
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