Anti-RAB11A monoclonal antibody, clone 4E3G9

Antibody Isotype

IgG

Clone

4E3G9

Species Reactivity

Mouse

Immunogen

Full length protein corresponding to Human Rab11A aa 1-216.Sequence: MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFAT RSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYE NVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSF IETSALDSTNVEAAFQTILTEIYRIVSQKQMSD

Conjugate

Application Notes

WB: 1/100 - 1/1000; ELISA: 1/100 - 1/5000; IHC-P: 1/50 - 1/100.

Alternative Names

RAB11A; RAB11A, member RAS oncogene family; ras-related protein Rab-11A; YL8; rab-11; RAB 11A, member oncogene family; MGC1490;

Entrez Gene ID

UniProt ID

Antigen Description

Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.

Pathway

Aquaporin-mediated transport, organism-specific biosystem; Arf6 downstream pathway, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Notch signaling pathway, organism-specific biosystem;