The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene.
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References
HUMAN GENERATION, MEMORY AND POETIC CREATION: FROM THE PURGATORIO TO THE PARADISO
Statius' scientific digression on the generation of the fetus and the formation of the fictive body in the afterlife occupies a large part of canto XXV of Dante's Purgatorio. This article will examine the metaphorical relevance of that technical exposition to Dante's poetics. The analogy between procreation and poetic creation appeari to be consistent once the scientific lesson on embryology of canto XXV is understood as mirroring the definition of the Dolce Stil Novo offered by Dante in the previous canto (Purg. XXIV). The second part of this article stresses the importance of cantos XXIV and XXV as an authorization to investigate the presence, in Dante's Comedy, of a particular notion of purely rational memory derived from Augustine's speculation. The allusion to an Augustinian conception of memory in Purgatorio XXV opens the possibility of considering its presence in the precisely intellectual dimension of Paradiso.
Regulation of purine biosynthetic genes expression in Salmonella typhimurium .4. O-c mutation site of purG and its function analysis
Salmonella typhimurium 5' phosphoribosylformylglycinamide (FGAR) amidotransferase encoded by purG gene catalyzes the conversion of FGAR to formylglycinamide ribonucleotide (FGAM) in the presence of glutamine and ATP for the de novo purine nucleotide biosynthesis. purG gene is negatively regulated by a repressor-operator system. The O+ purG and O-c purG were cloned respectively in vivo. Restriction enzymes analysis of preliminary clones pLBG-1 (O+) and pLBG-2 (O-c) were carried our. The hybrid plasmids pLB1933 (O+) and pLB1927 (O-c) containing 5' control region of purG were constructed and the DNA sequences were determined respectively. DNA sequences data showed that O-c mutation of purG occurred at the 3rd position of 16 bp PUR box in the 5' control region (G --> A). Gel retardation experiment indicated that the repressor bound well with O+ PUR hox, bur nor with O-c PUR box. The result strongly supported the idea that PUR box is the binding region of repressor protein and the 3rd position base G of PUR box is essential for the binding function with repressor protein.
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