Anti-PUM1 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human Pumilio 1 aa 1-1186.Sequence: MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQP AANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGG GGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGK KFWETDESSKDGPKGIFLGDQWRDSAWGT

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

PUM1; pumilio RNA-binding family member 1; PUMH; HSPUM; PUMH1; PUML1; pumilio homolog 1; pumilio-1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.

Pathway

Clathrin derived vesicle budding; Membrane Trafficking;