Anti-PTX3 monoclonal antibody, clone 3C20

Antibody Isotype

IgG2a

Clone

3C20

Species Reactivity

Human

Immunogen

PTX3 (NP_002843, 282 a.a. ~ 380 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

PTX3; pentraxin 3, long; pentaxin related gene, rapidly induced by IL 1 beta , pentraxin related gene, rapidly induced by IL 1 beta , TNFAIP5, tumor necrosis factor, alpha induced protein 5; pentraxin-related protein PTX3; TSG 14; pentraxin-3; TNF alpha-i

Entrez Gene ID

UniProt ID

Antigen Description

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle.