General Notes
This product (Catalog No. DPABH-08317) is a rabbit-derived IgG polyclonal antibody raised against human PTPN3, targeting the amino acid region 11–110 of the protein. This antibody exhibits cross-reactivity with PTPN3 from mouse, rat, dog, cow, horse, and sheep. It has been affinity purified by Protein A. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
DPABH-08317 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
DPABH-08317 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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