The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene.
Pathway
Calcium signaling pathway; Class A/1 (Rhodopsin-like receptors); Eicosanoid ligand-binding receptors; G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like; GPCRs, Other; Gastrin-CREB signalling pathway via PKC and MAPK; Neuroactive ligand-receptor interaction; Prostaglandin Synthesis and Regulation.
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