PTCH2 (NP_003729, 79 a.a. ~ 188 a.a) partial recombinant protein with GST tag. The sequence is ETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQA ALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTP
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
Pathway
Basal cell carcinoma; Class B/2 (Secretin family receptors); Hedgehog Signaling Pathway; Hedgehog signaling pathway
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