Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase.
Pathway
APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc2 mediated degradation of mitotic proteins; AUF1 (hnRNP D) destabilizes mRNA; Activation of NF-kappaB in B cells.
Citations
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