Anti-PSMD2 monoclonal antibody, clone 2I4

Antibody Isotype

IgG2a

Clone

2I4

Species Reactivity

Human

Immunogen

Recombinant full length Human Proteasome 26S S2 produced in HEK293T cells (NP_002799).

Conjugate

Application Notes

WB: 1/2000;

Alternative Names

PSMD2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; 26S proteasome non-ATPase regulatory subunit 2; MGC14274; P97; Rpn1; S2; TRAP2; 55.11 protein; protein 55.11; TNFR-associated protein 2; 26S proteasome subunit p97; 26S proteasome regulato

Entrez Gene ID

UniProt ID

Antigen Description

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem;