Anti-PSMC4 monoclonal antibody, clone FQS0021(C)

Antibody Isotype

IgG

Clone

FQS0021(C)

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) (N terminal)

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

PSMC4; proteasome (prosome, macropain) 26S subunit, ATPase, 4; MIP224; 26S protease regulatory subunit 6B; MB67 interacting protein; MGC8570; MGC13687; MGC23214; protease 26S subunit 6; S6; Tat binding protein 7; TBP 7; TBP7; TBP-7; Tat-binding protein 7;

Entrez Gene ID

UniProt ID

Antigen Description

TBP7 (or proteasome 26S subunit, ATPase, 4) is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. It is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem;