Anti-PSMC3IP monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human PSMC3IP is used for rabbit immunization.

Conjugate

Alternative Names

PSMC3IP; PSMC3 interacting protein; homologous-pairing protein 2 homolog; GT198; HUMGT198A; TBP 1 interacting protein; TBPIP; DBD-interacting; TBP-1-interacting protein; nuclear receptor coactivator GT198; tat-binding protein 1-interacting protein; protea

Entrez Gene ID

UniProt ID

Antigen Description

Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; Meiosis, organism-specific biosystem; Meiotic Recombination, organism-specific biosystem;