Anti-PSMB6 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

PSMB6 (AAH00835, 1 a.a. ~ 239 a.a) full-length recombinant protein with GST tag. The sequence is MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI ANRVTDELTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA

Conjugate

Alternative Names

PSMB6; proteasome (prosome, macropain) subunit, beta type, 6; Y; LMPY; DELTA; proteasome subunit beta type-6; proteasome subunit Y; macropain delta chain; proteasome delta chain; proteasome subunit delta; proteasome catalytic subunit 1; PSY large multifun

Entrez Gene ID

UniProt ID

Antigen Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Pathway

APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc2 mediated degradation of mitotic proteins; AUF1 (hnRNP D) destabilizes mRNA; Activation of NF-kappaB in B cells.