Anti-PSF1 monoclonal antibody (DMAB4576RM)

Rat anti-Mouse PSF1 monoclonal antibody for WB, IHC, ICC Datasheet

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Specifications


Host Species
Rat
Antibody Isotype
IgG
Clone
C1317M
Species Reactivity
Mouse
Immunogen
Recombinant full-length Mouse PSF1
Conjugate
Unconjugated

Target


Alternative Names
PSF1; DNA replication complex GINS protein PSF1; GINS complex subunit 1; GINS1; partner of sld five-1; partner of sld5
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
PSF1 is a member of the heterotetrameric GINS complex which is essential for formation of replication forks and replisome progression in DNA replication. The precise function of GINS is unclear, but it is thought to activate the MCM2-7 complex and also to interact with DNA polymerases alpha and epsilon. The other members of the GINS complex are PSF2, PSF3 and SLD5. Suitable for use in Western blot, Immunohistochemistry and Immunocytochemistry.   Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. The function about PSF1 antigen include protein binding.
Pathway
Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA strand elongation, organism-specific biosystem; S Phase, organism-specific biosystem; Synthesis of DNA, organism-specific biosystem; Unwinding of DNA, orga.

Citations


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References


Kinugasa, Y; Matsui, T; et al. CD44 Expressed on Cancer-Associated Fibroblasts Is a Functional Molecule Supporting the Stemness and Drug Resistance of Malignant Cancer Cells in the Tumor Microenvironment. STEM CELLS 32:145-156(2014).
De Falco, M; Ferrari, E; et al. The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase. EMBO REPORTS 8:99-103(2007).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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