This product (Catalog No. DPABH-04014) is a rabbit-derived polyclonal antibody raised against human PRPF19. This antibody exhibits cross-reactivity with PRPF19 from mouse and rat. It has been affinity purified by Protein A. Enables identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in several processes, including DNA damage checkpoint signaling; mRNA splicing, via spliceosome; and protein K63-linked ubiquitination. Acts upstream of or within protein polyubiquitination. Located in cytoplasm; nuclear lumen; and site of double-strand break. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. DPABH-04014 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:100–1:200) applications. DPABH-04014 is supplied as a liquid formulation in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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