Anti-PRKCQ (aa 1-100) polyclonal antibody

Species Reactivity

Human

Immunogen

PRKCQ (NP_006248, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. The sequence is MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNN

Conjugate

Alternative Names

PRKCQ; protein kinase C, theta; PRKCT; nPKC-theta; protein kinase C theta type;

Entrez Gene ID

UniProt ID

Antigen Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.

Pathway

Adaptive Immune System; Apoptosis; Apoptotic execution phase; B Cell Receptor Signaling Pathway