Rabbit Anti-Human PRKAR2A Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Fusion protein of human PRKAR2A

Conjugate

Application Notes

WB: 1:500-2000
IHC: 1: 100-200

General Notes

This product (Catalog No. DPABH-14558) is a rabbit-derived polyclonal antibody raised against human PRKAR2A. It has been affinity purified by Protein A. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
DPABH-14558 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1: 100-200) applications.
DPABH-14558 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

PKR2; PRKAR2

Entrez Gene ID

UniProt ID