The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.
Pathway
Activation of the pre-replicative complex, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA Replication Pre-Initiation, organism-specific biosystem.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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SHIRATORI, A; OKUMURA, K; et al. ASSIGNMENT OF THE 49-KDA (PRIM1) AND 58-KDA (PRIM2A AND PRIM2B) SUBUNIT GENES OF THE HUMAN DNA PRIMASE TO CHROMOSOME BANDS 1Q44 AND 6P11.1-P12. GENOMICS 28:350-353(1995).
Hodgkinson, A; Eyre-Walker, A; et al. The Genomic Distribution and Local Context of Coincident SNPs in Human and Chimpanzee. GENOME BIOLOGY AND EVOLUTION 2:547-557(2010).
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COA
Certificate of Analysis
