Anti-PRCP polyclonal antibody (DPABH-14201)

Rabbit anti-Human PRCP (aa 46-317) polyclonal antibody for WB,IHC-P

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
Recombinant fragment within Human PRCP aa 46-317. The exact sequence is proprietary. (With tag; BC001500).Database link: P42785
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/200 - 1/1000; IHC-P: 1/20 - 1/100.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
PRCP; prolylcarboxypeptidase (angiotensinase C); lysosomal Pro-X carboxypeptidase; HUMPCP; PCP; angiotensinase C
Entrez Gene ID
UniProt ID

Product Background


Pathway
Formation of Fibrin Clot (Clotting Cascade); Hemostasis; Intrinsic Pathway; Protein digestion and absorption;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Prolylcarboxypeptidase: A cardioprotective enzyme

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Authors: Mallela, J.; Yang, J.; Shariat-Madar, Z.

Prolycarboxypeptidase (PRCP) is involved in regulating the blood flow through active tissues in order to preserve the internal environment. The expression of PRCP in tissues is determined by a number of pharmacological stimuli such as glucocorticoids and a combination of dexamethasone plus the mu-opioid receptor agonise [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate. PRCP is all enzyme which is associated with preeclampsia, rheumatoid arthritis, and tonsillitis. The interplay between inward cellular signalling required for induced and basal transcription, and PRCP expression have not been mechanistically characterized. Molecules modulated by PROP include angiotensin II (Ang II), angiotensin III (Ang III), alpha-MSH, and prekallikrein (PK), demonstrating its cardiovascular protective role. In addition to regulating vascular tone, PROP may modulate proliferation, cell migration, and angiogenesis through regulating angiotensin molecules - and bradykinin - induced endothelium activation. The anti-hypertensive and proinflammatory properties of PRCP implicate that this enzyme may well be all accessible target for anti-inflammatory therapy. Published by Elsevier Ltd.

THE QUADROG ROBOT, A PARALLEL ROBOT WITH A CONFIGURABLE PLATFORM FOR HAPTIC APPLICATIONS

INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE, 2015, VOL 5C

Authors: Hamaza, Salua; Lambert, Patrice; Carricato, Marco; Herder, Just

This paper explores the fundamentals of parallel robots with configurable platforms (PRCP), as well as the design and the kinematic analysis of those. The concept behind PRCP is that the rigid (non-configurable) end-effector is replaced by a closed loop chain, the configurable platform. The use of a closed-loop chain allows the robot to interact with the environment from multiple contact points on the platform, which reflects the presence of multiple end-effectors. This results in a robot that successfully combines motion and grasping capabilities into a structure that provides an inherent high stiffness. This paper aims to introduce the QuadroG robot, a 4 degrees of freedom PRCP which finely merges planar motion together with grasping capabilities.

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