This product (Catalog No. DPABH-20999) is a rabbit-derived polyclonal antibody raised against human PPP1R3D. This antibody exhibits cross-reactivity with PPP1R3D from mouse and rat. It has been affinity purified by Protein A. Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. DPABH-20999 is suitable for use in Western blot (WB) (1:1,000–1:3,000) application. DPABH-20999 is supplied as a liquid formulation in PBS containing 50% glycerol, and 0.02% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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