Anti-PPP1R12B monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human PPP1R12B is used for rabbit immunization.

Conjugate

Alternative Names

PPP1R12B; protein phosphatase 1, regulatory subunit 12B; MYPT2; PP1bp55; protein phosphatase 1 regulatory subunit 12B; myosin phosphatase target subunit 2; myosin phosphatase, target subunit 2; myosin phosphatase-targeting subunit 2; protein phosphatase 1

Entrez Gene ID

UniProt ID

Antigen Description

Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome.

Pathway

Cell Cycle; Cell Cycle, Mitotic; Focal adhesion; G2/M Transition; Mitotic G2-G2/M phases; Proteoglycans in cancer; Regulation of PLK1 Activity at G2/M Transition; Regulation of actin cytoskeleton; Vascular smooth muscle contraction.