Anti-PPM1A monoclonal antibody, clone 8G23 Knockout Validated

Name: Anti-PPM1A monoclonal antibody, clone 8G23
SKU: DCABH-3209
Rating: 5 (1 reviews)

Mouse anti-Human PPM1A monoclonal antibody for WB, ELISA, FC

Write a review

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

8G23

Species Reactivity

Human; Monkey

Immunogen

Purified recombinant fragment corresponding to amino acids 202-382 of Human PPM1A, expressed in E. coli.

Conjugate

Unconjugated

Applications

Application Notes

WB: 1/500 - 1/2000; ELISA: 1/10000; Flow Cyt: 1/200 - 1/400;

Target

Alternative Names

PPM1A; protein phosphatase, Mg2+/Mn2+ dependent, 1A; protein phosphatase 1A (formerly 2C), magnesium dependent, alpha isoform; protein phosphatase 1A; MGC9201; phosphatase 2C alpha; PP2CA; PP2Calpha; protein phosphatase 2C; alpha isoform; protein phosphat

Entrez Gene ID

5494

UniProt ID

A0A024R6A5

Product Background

Antigen Description

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.

Pathway

BMP receptor signaling, organism-specific biosystem; Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem;

Citations