General Notes
This product (Catalog No. DPABH-21836) is a rabbit-derived polyclonal antibody raised against human PPIF, targeting the amino acid region 45–196 of the protein. This antibody exhibits cross-reactivity with Human PPIF from mouse and rat. It has been affinity purified by Protein A. Peptidylprolyl isomerase F (PPIF) is a protein-coding gene in humans that encodes a mitochondrial enzyme belonging to the cyclophilin subfamily of peptidyl-prolyl cis-trans isomerases (PPIases). Located on chromosome 10q22.3, PPIF produces a 178-amino-acid protein known as cyclophilin D (CypD), which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides to accelerate protein folding. This enzyme is a key component of the mitochondrial permeability transition pore (mPTP) complex in the inner mitochondrial membrane, regulating pore opening that triggers apoptotic and necrotic cell death under stress conditions.
DPABH-21836 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-21836 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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