This locus represents naturally occurring read-through transcription between the adjacent PPAN and P2RY11 genes. Alternative splicing results in two transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This transcript is found to be ubiquitously expressed and is up-regulated by agents inducing granulocytic differentiation. However, its functional significance in vivo remains unclear.
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (s) signalling events; GPCR ligand binding; Nucleotide-like (purinergic) receptors
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