Anti-POU2F1 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human Oct-1 aa 1-743.Sequence: MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQT QLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAG ATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQ

Conjugate

Application Notes

WB: 1 μg/ml; ICC/IF: 10 μg/ml;

Alternative Names

POU2F1; POU class 2 homeobox 1; OCT1; OTF1; oct-1B; POU domain, class 2, transcription factor 1; NF-A1; OTF-1; oct-1; octamer-binding protein 1; Octamer-binding transcription factor-1; octamer-binding transcription factor 1;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor that binds to the octamer motif (5-ATTTGCAT-3) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Pathway

ATF-2 transcription factor network; Calcium signaling in the CD4+ TCR pathway; Gene Expression; RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription