POT1 (NP_056265, 1 a.a. ~ 95 a.a) partial recombinant protein with GST tag. The sequence is MSLVPATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCL LFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQG
Conjugate
Unconjugated
Target
Alternative Names
POT1; protection of telomeres 1; CMM10; HPOT1; protection of telomeres protein 1; protection of telomeres 1 homolog; POT1-like telomere end-binding protein;
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
Pathway
Cell Cycle; Cellular responses to stress; DNA Damage/Telomere Stress Induced Senescence; Meiotic synapsis.
Citations
Publication ()
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