Anti-POLR3G monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human POLR3G is used for rabbit immunization.

Conjugate

Alternative Names

POLR3G; polymerase (RNA) III (DNA directed) polypeptide G (32kD); RPC7; RPC32; DNA-directed RNA polymerase III subunit RPC7; RNA polymerase III subunit C7; RNA polymerase III 32 kDa subunit; DNA-directed RNA polymerase III subunit G; DNA-directed RNA poly

Entrez Gene ID

UniProt ID

Antigen Description

POLR3G (polymerase (RNA) III (DNA directed) polypeptide G (32kD)) is a protein-coding gene. Diseases associated with POLR3G include capillary leak syndrome, and juvenile myelomonocytic leukemia, and among its related super-pathways are RNA Polymerase III Transcription Initiation and Purine metabolism. GO annotations related to this gene include DNA-directed RNA polymerase activity. An important paralog of this gene is POLR3GL. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.

Pathway

Cytosolic DNA-sensing pathway; Cytosolic sensors of pathogen-associated DNA; Epstein-Barr virus infection; Gene Expression; Immune System; Innate Immune System; Pyrimidine metabolism; Pyrimidine metabolism; RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Chain Elongation;