This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Pathway
Delta-Notch Signaling Pathway; Other types of O-glycan biosynthesis; Pre-NOTCH Expression and Processing; Pre-NOTCH Processing in the Endoplasmic Reticulum; Signal Transduction; Signaling by NOTCH
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