Specifications
Immunogen
Recombinant protein corresponding to amino acids 57-261 of human PNPO.
Applications
Application Notes
WB (1:500-1:5000) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
PNPO; pyridoxamine 5-phosphate oxidase; pyridoxine 5 phosphate oxidase; pyridoxine-5-phosphate oxidase; PDXPO; pyridoxamine-phosphate oxidase; pyridoxal 5-phosphate synthase; pyridoxine 5-phosphate oxidase; FLJ10535;
Product Background
Antigen Description
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.
Pathway
Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Selenium Pathway, organism-specific biosystem; Vitamin B6 metabolism, organism-specific biosystem; Vitamin B6 metabolism, conserved biosystem;
Citations
Publication ()
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COA
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