Anti-PNN monoclonal antibody, clone 3C5

Antibody Isotype

IgG2a

Clone

3C5

Species Reactivity

Human; Rat

Immunogen

PNN (NP_002678, 201 a.a. ~ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

PNN; pinin, desmosome associated protein; pinin; memA; SR-like protein; neutrophil protein; nuclear protein SDK3; domain-rich serine protein; desmosome-associated protein; melanoma metastasis clone A protein; 140 kDa nuclear and cell adhesion-related phos

Entrez Gene ID

UniProt ID

Antigen Description

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.

Pathway

Exon junction complex (EJC), organism-specific biosystem; RNA transport, organism-specific biosystem; RNA transport, conserved biosystem; mRNA surveillance pathway, organism-specific biosystem; mRNA surveillance pathway, conserved biosystem;