Anti-PLOD1 (aa 19-114) polyclonal antibody

Species Reactivity

Human

Immunogen

PLOD1 (NP_000293, 19 a.a. ~ 114 a.a) partial recombinant protein with GST tag. The sequence is KGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGLGEDWNVEKGTSAGGGQKV RLLKKALEKHADKEDLVILFADSYDVLFASGPRELL

Conjugate

Alternative Names

PLOD1; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; LH; LH1; LLH; EDS6; PLOD; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; lysine hydroxylase; lysyl hydroxlase 1; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1;

Entrez Gene ID

UniProt ID

Antigen Description

Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity.

Pathway

Collagen biosynthesis and modifying enzymes; Extracellular matrix organization; Lysine degradation;