Anti-PLEKHM2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human PLEKHM2 is used for rabbit immunization.

Conjugate

Alternative Names

PLEKHM2; pleckstrin homology domain containing, family M (with RUN domain) member 2; pleckstrin homology domain-containing family M member 2; KIAA0842; sifA and kinesin-interacting protein; PH domain-containing family M member 2; novel RUN and PH domain-c

Entrez Gene ID

UniProt ID

Antigen Description

PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

Pathway

Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem;