Anti-PLEKHG2 monoclonal antibody (DCABH-16457) Made to order

Rabbit anti-Human PLEKHG2 monoclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human PLEKHG2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
PLEKHG2; pleckstrin homology domain containing, family G (with RhoGef domain) member 2; pleckstrin homology domain-containing family G member 2; ARHGEF42; CLG; FLJ00018
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein). The function about PLEKHG2 antigen include Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity.
Pathway
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosyst.

Citations


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References


Tellermann, A; Witte, T; et al. Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections. HIV MEDICINE 16:114-121(2015).
Zinovyeva, M; Sveshnikova, E; et al. Molecular cloning, sequence and expression pattern analysis of the mouse orthologue of the leukemia-associated guanine nucleotide exchange factor. GENE 337:181-188(2004).

Custom Antibody Labeling


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