Anti-PLD6 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to amino acids 150-252 of Human PLD6.

Conjugate

Unconjugated

Application Notes

IHC-P: 1/10 - 1/20;

Alternative Names

PLD6; phospholipase D family, member 6; ZUC; mitochondrial cardiolipin hydrolase; PLD 6; mitoPLD; phospholipase D6; choline phosphatase 6; protein zucchini homolog; mitochondrial phospholipase; phosphatidylcholine-hydrolyzing phospholipase D6;

Entrez Gene ID

201164

UniProt ID

Q8N2A8

Antigen Description

Cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

Pathway

Glycerophospholipid biosynthesis; Metabolism of lipids and lipoproteins; Synthesis of PG; phospholipases

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More