Specifications
Immunogen
PLCD1 (AAH50382, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. The sequence is MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMR TPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIV
Target
Alternative Names
PLCD1; phospholipase C, delta 1; NDNC3; PLC-III; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; PLC-delta-1; phospholipase C-III; phosphoinositide phospholipase C-delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta
Product Background
Antigen Description
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Pathway
Calcium signaling pathway; D-myo-inositol (1,4,5)-trisphosphate biosynthesis; D-myo-inositol-5-phosphate metabolism; Inositol phosphate metabolism
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Jiang, LL; Ke, CL; et al. Listeria monocytogenes mutants carrying Newcastle disease virus F gene fused to its actA and plcB: In vitro expression and immunogenicity in chickens. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 39:57-66(2007).
Hsieh, HL; Wu, CY; et al. BK-induced cytosolic phospholipase A(2) expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappa B activation in rat brain astrocytes. JOURNAL OF CELLULAR PHYSIOLOGY 206:246-254(2006).
COA
Certificate of Analysis