PLA2G2F (phospholipase A2, group IIF) is a protein-coding gene. Diseases associated with PLA2G2F include toxoplasmosis, and pancreatitis, and among its related super-pathways are Acyl chain remodelling of PC and Glycerophospholipid biosynthesis. GO annotations related to this gene include phospholipase A2 activity and calcium ion binding. An important paralog of this gene is ENSG00000258417. PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.
Pathway
Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodelling of PG; Acyl chain remodelling of PI; Acyl chain remodelling of PS; Arachidonic acid metabolism; Ether lipid metabolism; Fat digestion and absorption; Glycerophospholipid biosynthesis; Glycerophospholipid metabolism; Linoleic acid metabolism.
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