Anti-PIK3R6 (aa 661-754) polyclonal antibody

Species Reactivity

Human

Immunogen

C17orf38 (NP_001010855, 661 a.a. ~ 754 a.a) partial recombinant protein with GST tag. The sequence is GKSFSTVTNTFRTNNIQIQSRDQRLLTLSLDKDDQRTFRDVVRFEVAPCPEPCSGAQKSK APWLNLHGQQEVEAIKAKPKPLLMPINTFSGIVQ

Conjugate

Alternative Names

PIK3R6; phosphoinositide-3-kinase, regulatory subunit 6; C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP); phosphoinositide 3-kinase regulatory subunit 6; p84 PI3K adapter protein; PI3Kgamma adapter protein of 87 kDa; p87 phosphoinositide 3-kinase gamm

Entrez Gene ID

UniProt ID

Antigen Description

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants.

Pathway

3-phosphoinositide biosynthesis; G beta:gamma signalling through PI3Kgamma; GPCR downstream signaling; Hemostasis.