Anti-PIK3AP1 monoclonal antibody, clone 8H0

Antibody Isotype

IgG1

Clone

8H0

Species Reactivity

Dog; Human; Monkey

Immunogen

Recombinant full length protein corresponding to Human PIK3AP1 (NP_689522.2) produced in HEK293T cells.

Conjugate

Application Notes

WB: 1/500 - 1/2000; Flow Cyt: 1/100; ICC/IF: 1/100;

Alternative Names

PIK3AP1; phosphoinositide-3-kinase adaptor protein 1; phosphoinositide 3-kinase adapter protein 1; BCAP; FLJ35564; B cell adaptor protein; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1; RP11-34E5.3;

Entrez Gene ID

UniProt ID

Antigen Description

Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity). May be involved in the survival of mature B cells via activation of REL.

Pathway

Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; Immune System, organism-specific biosystem; Signaling by the B Cell Receptor (BCR), organism-specific biosystem;