Anti-PIGF monoclonal antibody (DCABH-12915)

Rabbit Anti-Human PIGF monoclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human PIGF is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
PIGF; phosphatidylinositol glycan anchor biosynthesis, class F; phosphatidylinositol glycan, class F; phosphatidylinositol-glycan biosynthesis class F protein; PIG-F; GPI11 homolog
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PIGF (Phosphatidylinositol Glycan Anchor Biosynthesis Class F) is a Protein Coding gene. Diseases associated with PIGF include pre-eclampsia and preeclampsia/eclampsia 1. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ethanolaminephosphotransferase activity. This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described.
Antigen Description
This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI. Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.
Pathway
Diurnally regulated genes with circadian orthologs, organism-specific biosystem; GPI-anchor biosynthesis, core oligosaccharide, organism-specific biosystem; GPI-anchor biosynthesis, core oligosaccharide, conserved biosystem; Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, organism-specific biosystem; Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem.

Citations


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References


Robak, E; Kierstan, M; et al. Circulating endothelial cells and angiogenic proteins in patients with systemic lupus erythematosus. LUPUS 18:332-341(2009).
Fitzpatrick, TE; Lash, GE; et al. Inhibition of breast carcinoma and trophoblast cell invasiveness by vascular endothelial growth factor. EXPERIMENTAL CELL RESEARCH 283:247-255(2003).

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