Anti-PIAS4 monoclonal antibody, clone 8C9

Antibody Isotype

IgG1

Clone

8C9

Species Reactivity

Mouse; Human

Immunogen

Recombinant fusion protein containing the C-terminal region of Human E3 SUMO-protein ligase PIAS4 (Q8N2W9) with proprietary tag.

Conjugate

Application Notes

WB: 1/1000 - 1/5000;

Alternative Names

PIAS4; protein inhibitor of activated STAT, 4; E3 SUMO-protein ligase PIAS4; FLJ12419; Piasg; PIASY; zinc finger; MIZ type containing 6; ZMIZ6; PIAS-gamma; zinc finger, MIZ-type containing 6; protein inhibitor of activated STAT protein 4; protein inhibito

Entrez Gene ID

UniProt ID

Antigen Description

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; IFN-gamma pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem.