Anti-PHKA1 (aa 631-730) polyclonal antibody

Species Reactivity

Human

Immunogen

PHKA1 (NP_002628, 631 a.a. ~ 730 a.a) partial recombinant protein with GST tag. The sequence is DYDDNYDYLESGNWMNDYDSTSHARCGDEVARYLDHLLAHTAPHPKLAPTSQKGGLDRFQ AAVQTTCDLMSLVTKAKELHVQNVHMYLPTKLFQASRPSF

Conjugate

Alternative Names

PHKA1; phosphorylase kinase, alpha 1 (muscle); PHKA; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; phosphorylase kinase alpha M subunit; phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis; phosphorylase b kinase regula

Entrez Gene ID

UniProt ID

Antigen Description

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010]

Pathway

Calcium signaling pathway; Disease; Glycogen Metabolism; Glycogen storage diseases