Rabbit Anti-Human PHF17 (a.a. 1-300) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant human PHF17 protein; Source: E. coli derived, T-HIS; Tag: 6*His; Domain: 1-300 aa of BC032376

Conjugate

Application Notes

WB: 1:500-1:1000

General Notes

This product (Catalog No. DPABH-04996) is a rabbit-derived polyclonal antibody raised against human PHF17, targeting the amino acid region 1–300 of the protein. It has been affinity purified by Protein A. PHF17 was identified as a protein partner of the von Hippel-Lindau tumor suppressor pVHL. It is one component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. It can act as a transcriptional coactivator that promote acetylation of nucleosomal histone H4 by KAT5. In addition, it ubiquitinates both phosphorylated and non-phosphorylated β-catenin and therefore regulates canonical Wnt signaling in both Wnt-off and Wnt-on phases. PHF17 exist several isoforms with molecular weight 100-110 and 55-65 kDa.
DPABH-04996 is suitable for use in Western blot (WB) (1:500–1:1,000) application.
DPABH-04996 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Jade family PHD finger protein 1; JADE1; PHF 17; Protein Jade-1

Entrez Gene ID

UniProt ID