Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Profilin 2 aa 50 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: P35080
Applications
Application Notes
WB: 1/1000 - 1/5000; IP: 1/10 - 1/100;
Target
Alternative Names
PFN2; profilin 2; profilin-2; profilin II; PFL; D3S1319E;
Product Background
Antigen Description
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Pathway
Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, conserved biosystem; Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem; Shigellosis, organism-specific biosystem;
Citations
Publication ()
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COA
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