General Notes
This product (Catalog No. DPABH-28456) is a rabbit-derived polyclonal antibody raised against human PFKFB4. It has been affinity purified by Protein A. The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene.
DPABH-28456 is suitable for use in Western blot (WB) (1:200–1:1,000), IHC (1:25–1:100) applications.
DPABH-28456 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Alternative Names
6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4; 6PF-2-K/Fru-2,6-P2ase 4
COA
Publication 
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