Specifications
Immunogen
A synthetic peptide corresponding to human PFKFB2. The sequence is SEQNNNSYETKTP-C
Applications
Application Notes
ELISA: 1:16000. & The optimal working dilution should be determined by the end user.
Target
Alternative Names
PFKFB2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; PFK-2/FBPase-2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; PFK/FBPase 2; PFKFB, cardiac; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme; fructose-2,6-bisphospha
Product Background
Antigen Description
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.
Pathway
AMPK signaling pathway; Disease; Fructose and mannose metabolism; Glycogen storage diseases
Citations
Publication ()
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COA
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