Anti-PFKFB1 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human PFKFB1 is used for rabbit immunization.

Conjugate

Alternative Names

PFKFB1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; F6PK; HL2K; PFRX; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; fructose-6-phosphate,2-kinase:fructose-2,6

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Pathway

Fructose and mannose metabolism; Gluconeogenesis; Glucose metabolism; Glycolysis; HIF-1 signaling pathway; Integration of energy metabolism; Metabolism; Metabolism of carbohydrates; PKA-mediated phosphorylation of key metabolic factors; PP2A-mediated dephosphorylation of key metabolic factors;