The Role of Prefoldin and Its Subunits in Tumors and Their Application Prospects in Nanomedicine
CANCER MANAGEMENT AND RESEARCH
Authors: Mo, Shao-jian; Zhao, Hai-Chao; Tian, Yan-zhang; Zhao, Hao-Liang
Abstract
Prefoldin (PFDN) is a hexameric chaperone complex that is widely found in eukaryotes and archaea and consists of six different subunits (PFDN1-6). Its main function is to transfer actin and tubulin monomers to the eukaryotic cell cytoplasmic chaperone protein (c-CPN) specific binding during the assembly of the cytoskeleton, to stabilize the newly synthesized peptides so that they can be folded correctly. The current study found that each subunit of PFDN has different functions, which are closely related to the occurrence, development and prognosis of tumors. However, the best characteristics of each subunit have not been fully affirmed. The connection between research and tumors can change the understanding of PFDN and further extend its potential prognostic role and structural function to cancer research and clinical practice. This article mainly reviews the role of canonical PFDN and its subunits in tumors and other diseases, and discusses the potential prospects of the unique structure and function of PFDN in nanomedicine.
Transethnic genome-wide scan identifies novel Alzheimer's disease loci
ALZHEIMERS & DEMENTIA
Authors: Jun, Gyungah R.; Chung, Jaeyoon; Mez, Jesse; Barber, Robert; Beecham, Gary W.; Bennett, David A.; Buxbaum, Joseph D.; Byrd, Goldie S.; Carrasquillo, Minerva M.; Crane, Paul K.; Cruchaga, Carlos; De Jager, Philip; Ertekin-Taner, Nilufer; Evans, Denis; Fallin, M. Danielle; Foroud, Tatiana M.; Friedland, Robert P.; Goate, Alison M.; Graff-Radford, Neill R.; Hendrie, Hugh; Hall, Kathleen S.; Hamilton-Nelson, Kara L.; Inzelberg, Rivka; Kamboh, M. Ilyas; Kauwe, John S. K.; Kukull, Walter A.; Kunkle, Brian W.; Kuwano, Ryozo; Larson, Eric B.; Logue, Mark W.; Manly, Jennifer J.; Martin, Eden R.; Montine, Thomas J.; Mukherjee, Shubhabrata; Naj, Adam; Reiman, Eric M.; Reitz, Christiane; Sherva, Richard; St George-Hyslop, Peter H.; Thornton, Timothy; Younkin, Steven G.; Vardarajan, Badri N.; Wang, Li-San; Wendlund, Jens R.; Winslow, Ashley R.; Haines, Jonathan; Mayeux, Richard; Pericak-Vance, Margaret A.; Schellenberg, Gerard; Lunetta, Kathryn L.; Farrer, Lindsay A.
Abstract
Introduction: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. Methods: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Results: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE epsilon 4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 x 10(-6)) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 x 10(-6)). Discussion: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
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